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This partial grant of exemption is subject to the following conditions:
1. The Airplane Flight Manual for the A380-800 must indicate that the maximum
indicated operating pressure altitude is 43,000 feet.
2. The Airplane Flight Manual must contain applicable flightdeck crew procedures for
rapid decompression event. The section of the Airplane Flight Manual for the A380-800 which
pertains to actions in the event of a decompression must state that the flightdeck crew should
initiate a descent at the maximum rate of descent and safe descent speed, which is typically the
maximum operating speed (VMO/MMO) assuming structural integrity of the airplane.
3. The petitioner must submit certification flight test data for the Model A380-800 that
corroborate the descent profiles used in the analysis to show that after decompression at an
airplane indicated operating pressure altitude of 43,000 feet, the cabin pressure altitude will not
exceed 25,000 feet for more than 3 minutes or 40,000 feet for more than 1 minute.
4. If dispatch is deemed appropriate with a malfunctioning system that is required to
ensure the airplane is capable of performing an emergency descent, then the Master Minimum
Equipment List (MMEL) must limit dispatch to a maximum flight altitude of 40,000 feet, unless
other regulations or limitations require a lower altitude.
Issued in Renton, Washington, on March 24, 2006.
/s/
Ali Bahrami
Manager
Transport Airplane Directorate
Aircraft Certification Service
ICAO Preliminary Unedited Version — October 2008
Doc 8984-AN/895
Part II
MANUAL OF CIVIL AVIATION MEDICINE
PRELIMINARY EDITION — 2008
International Civil Aviation Organization
PART II. AVIATION PHYSIOLOGY
Approved by the Secretary General
and published under his authority
INTERNATIONAL CIVIL AVIATION ORGANIZATION
ICAO Preliminary Unedited Version — October 2008
Part II
Chapter 1. PHYSIOLOGICAL FACTORS OF RELEVANCE TO FLIGHT SAFETY
Page
INTRODUCTION ................................................................................................. II-1-1
General ..............................................................................................................II-1-1
Human factors specified in Annexes................................................................. II-1-1
Working environment........................................................................................II-1-2
PHYSICS OF THE ATMOSPHERE................................................................... II-1-3
Barometric pressure...........................................................................................II-1-3
Hypoxia .............................................................................................................II-1-7
PROTECTIVE SYSTEMS ................................................................................... II-1-7
Cabin pressurization ..........................................................................................II-1-7
DECOMPRESSION.............................................................................................. II-1-9
COSMIC RADIATION......................................................................................... II-1-11
OZONE................................................................................................................... II-1-15
ACCELERATION EFFECTS.............................................................................. II-1-15
Short-term accelerations....................................................................................II-1-15
SENSORY ILLUSIONS........................................................................................ II-1-16
COMMUNICATIONS .......................................................................................... II-1-16
FLIGHT CREW WORKLOAD AND ITS
EFFECTS ON PERFORMANCE..................................................................... II-1-18
Fatigue............................................................................................................... II-1-18
FURTHER READING.......................................................................................... II-1-18
ICAO Preliminary Unedited Version — October 2008 II-1-1
INTRODUCTION
General
Throughout the ages of evolution most higher mammals, including humans, have become biologically
adjusted to an existence in the earth’s atmosphere at or near sea level. Departure from this natural habitat
by aerial flight can cause serious and possibly fatal disturbances unless either adequate physiological
adjustments have time to take place or artificial means for life support are employed, depending upon the
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