Other clinical symptoms
3.71 It is apparent that although some crew members have reacted to the fumes on the BAe 146, other crew members have had limited, or no reaction to the same exposure. One confidential submission to the inquiry advised that it appeared women were more susceptible than men to the fumes.74 Dr Winder stated:
There are a whole range of individual reasons why exposure may be increased and also a whole range of issues related to susceptibility. … There are a range of different factors which may underlie why some people are more affected than others.75
3.72 Dr Balouet told the inquiry in evidence:
… individual susceptibility is not the same with all people around the world and even within a small population. Some people would be really allergic, for example, to a compound and others would not. …
There might be genetic factors interfering with these problems. In fact, there are a number of enzymes, one of which especially play a major role in eliminating and controlling the effects of organophosphates. Particularly what we have seen from the preliminary studies is that the people sharing the two same enzymes will show very high effects, while those people who have either the R type or the 2 plus R type will not have such severe symptoms.76
3.73 In his evidence to the inquiry Dr Chris van Netten noted that:
The most sensitive people get sick first and they are your early warning signs of a potential problem. Often these people are looked upon as hypochondriacs or complainers or whatever else, and this is doing the system an injustice because it is actually quite dangerous to not pay attention to these people. They are really your early warning signs that something is wrong. The person next to you might get sick now because of a certain different physiology or background whereas you might get sick next, and this is the important component we have to worry about.77
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